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Literature summary for 2.1.1.361 extracted from

  • Wu, S.; Wang, W.; Kong, X.; Congdon, L.M.; Yokomori, K.; Kirschner, M.W.; Rice, J.C.
    Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression (2010), Genes Dev., 24, 2531-2542 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.361

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NQR1
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is phosphorylated at Ser 29 specifically by the cyclin-dependent kinase 1/cyclinB complex. This event results in the removal of the enzyme from mitotic chromosomes and prevents enzyme degradation but does not affect the enzyme's methyltransferase activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Synonyms

Synonyms Comment Organism
histone H4 Lys 20 monomethyltransferase
-
 Homo sapiens
KMT5a
-
 Homo sapiens
Pr-Set7
-
 Homo sapiens
SET8
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is required for normal cell cycle progression Homo sapiens