Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NQR1 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is phosphorylated at Ser 29 specifically by the cyclin-dependent kinase 1/cyclinB complex. This event results in the removal of the enzyme from mitotic chromosomes and prevents enzyme degradation but does not affect the enzyme's methyltransferase activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone H4 Lys 20 monomethyltransferase | - |
Homo sapiens |
KMT5a | - |
Homo sapiens |
Pr-Set7 | - |
Homo sapiens |
SET8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is required for normal cell cycle progression | Homo sapiens |